学习经历

2004-2008 厦门大学生物科学专业，学士

2008-2010 武汉大学细胞生物学专业，硕士

2010-2013 武汉大学细胞生物学专业，博士

工作经历与任职

2013-2017 美国北卡罗来纳大学教堂山分校癌症研究中心，博士后

2017-2019 美国北卡罗来纳大学教堂山分校病理系/癌症研究中心，研究助理教授 2019- 武汉大学医学研究院/教育部免疫与代谢前沿科学中心，教授

研究方向

肿瘤氧感知机制

获奖与荣誉

UNC Developmental Research Grant（2015）

Department of Defense U.S. Breast Cancer Research Program Breakthrough Fellowship（2016）

国家自然科学基金面上项目（2019, 2023）

国家重点研发计划青年科学家项目（项目骨干，2022）

湖北省自然科学基金重点类杰出青年项目（2020）

入选湖北省“BR计划”（2020）

湖北省自然科学基金群体项目（项目骨干，2022）

代表性论文

1. Jiang W#, Zhang M#, Gao C#, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J*. A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress. EMBO J. 2023 Oct 16;42(20):e113743.

2. Yan C#, Xiong J#, Zhou Z#, Li Q#, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H and Zhang J*. A cleaved METTL3 potentiates the METTL3-WTAP 1 interaction and breast cancer progression. eLife, 2023 May 10; 12.

3. Yan C, Gao R, Gao C, Hong K, Cheng M, Liu X, Zhang Q*and Zhang J*. FDXR drives primary and endocrine-resistant tumor cell growth in ER+ breast cancer via CPT1A-mediated fatty acid oxidation. Frontiers in Oncology, 2023 May 3; 13: 1847.

4. Xiong J, Yan C, Zhang Q# and Zhang J*. Alpha-Ketoglutarate-dependent enzymes in breast cancer and therapeutic implications. Endocrinology, 2023 May 19; bqad080.

5. Zhang J*, Zhang Q*. Using Seahorse Machine to Measure OCR and ECAR in Cancer Cells. Methods Mol Biol. 2019;1928:353-363.

6. Zhang J#, Wu T#, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG Jr, Baldwin AS, Zhang Q*. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018 Jul 20;361(6399):290-295.

Highlighted by Sanchez DJ and Simon MC. Transcriptional control of kidney cancer. Science 2018 Jul 20; 361 (6399): 226-227.

Commentary: ZHX2 is an oncogenic driver of kidney cancer. Cancer Discovery 2018 Jul 27

Faculty 1000（Exceptional）

7. Zhang J*, Zhang Q*. VHL and Hypoxia Signaling: Beyond HIF in Cancer. Biomedicines. 2018 Mar 19;6(1). pii: E35.

8. Zhang J#, Wang C#, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang CG, Pestell RG, Kaelin WG Jr, Liu XS and Zhang Q* (2015). EglN2 Associates with NRF-PGC1α Complex and Controls Mitochondrial Function in Breast Cancer. EMBO J, 2015 Dec 2; 34(23): 2953-70

9. Zhang J, Hu MM, Shu HB, Li S*. Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol. 2014 May;11(3):245-52.

10. Zhang J, Hu MM, Wang YY, Shu HB*. TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem. 2012 Aug 17;287(34):28646-55.