教育经历

2002-2006 南开大学生命科学学院，学士

2006-2012 美国科罗拉多大学医学中心 (University of Colorado Anschutz Medical Campus)，博士

工作经历与任职

2012-2015 美国哈佛大学医学院 (Harvard Medical School)，博士后

2015-2018 美国CRISPR基因治疗公司 (CRISPR Therapeutics)，资深研究员

2018- 武汉大学医学研究院，教授

社会兼职

2021- CELL Insight期刊 副主编

获奖情况

2019 获湖北省科技创新bairen计划

2012 获杰出博士论文奖 科罗拉多大学医学中心

2009 获第24届杰出科研奖 科罗拉多大学医学中心

研究领域

通过CRISPR技术直接修复胞内致病突变，或增强免疫细胞抗肿瘤功能来治疗癌症，从而将 CRISPR 技术转化为细胞疗法。 本课题组的目标是设计并构建完整的细胞基因编辑工具，并安全有效地将其递送至原代细胞中实现精准治疗。主要包括：

1. 新型CRISPR/Cas9工具的构建与优化；

2. 优化用于细胞治疗的大分子非病毒递送；

3. 探究CRISPR/Cas9 介导的细胞疗法，包括免疫疗法和对遗传疾病的治疗。

代表性论文

1. W Han#, HY Qiu#, S Sun#, ZC Fu#, GQ Wang#, X Qian, L Wang, X Zhai, J Wei, Wang Y, Guo YL, Cao GH, Ji RJ, Zhang YZ, Ma H, Wang H, Zhao M, Wu J, Bi LL, Chen QB, Li Z, Yu L, Mou X, Yin H, Yang L*, Chen J*, Yang B*, Zhang Y*. Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable offtarget mutations in human HSCs. Cell Stem Cell, 30,1-16, Dec 7th, 2023

2. J An #, CP Zhang#, HY Qiu#, HX Zhang#, QB Chen, YM Zhang, XL Lei, CX Zhang, H Yin*, Y Zhang*. Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway. Nature Biomedical Engineering, July 27, 2023

3. CP Zhang, HY Qiu, CX Zhang, YM Zhang, YZ Zhang, H Yin, KQ Zhang*, Y Zhang*. Efficient non-viral delivery of macromolecules in human primary hematopoietic stem cells and lymphocytes. Journal of Molecular and Cell Biology, 2023 Aug 3;15(3)

4. HX Zhang#, CX Zhang#, SH Lu, XH Tong, K Zhang, H Yin*, Y Zhang*. Cas12a-based one-pot SNP detection with high accuracy. Cell Insight, (2023): 100080. doi.org/10.1016/j.cellin.2023.100080

5. HY Qiu, RJ Ji, Y Zhang*. Current advances of CRISPR-Cas technology in cell therapy. Cell Insight, (2022): 100067 doi.org/10.1016/j.cellin.2022.100067

6. YJ Shi#, M Duan#, JM Ding#, FQ Wang, LL Bi, CX Zhang, YZ Zhang, JY Duan, AH Huang, XL Lei, H Yin, Y Zhang*. DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near PAMless cleavage by thermophilic Cas9. Molecular Cell, Nov 3;82(21):4160-4175, 2022

7. SH Lu#, XH Tong#, Y Han#, K Zhang, YZ Zhang, QB Chen, JY Duan, XL Lei, MH Huang, Y Qiu, DY Zhang, X Zhou, Y Zhang* and Hao Yin*. Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a. Nature Biomedical Engineering, 2022 Mar;6(3):286-297, 2022

专利

1. Patent number: PCT/CN2023/072703. COMPOSITIONS AND METHODS FOR TREATING ACUTE MYELOID LEUKEMIA. Ying Zhang, Guohua Cao, Ruijin Ji. Filing date January 17th, 2023 （申请）

2. Patent number: PCT/CN2021/107047. Compositions and Methods for Effective Delivery of Polynucleotides to Nuclei. Ying Zhang, Hao Yin, Chuanping Zhang. Filing date July 19th, 2021 （申请）

3. Patent number: PCT/CN2022/077097. Editing of Double-Stranded DNA with Relaxed PAM Requirement. Ying Zhang, Ya-jing Shi. Filing date Feb 21th, 2022 （申请）

4. Patent number: PCT/CN2022/070850. Compositions and Methods for Instant Nucleic Acid Detection. Hao Yin, Shuhan Lu, Ying Zhang, Xiaohan Tong, Kun Zhang, Xi Zhou, Dingyu Zhang. Filing date Jan 8th, 2021 （申请）

5. Patent number: WO2017141109 A1. Materials and methods for treatment of severe combined immunodeficiency (SCID) or omenn syndrome. Ying ZHANG, Chad Albert COWAN, Ante Sven LUNDBERG, Gregory Joseph COST. Filing date Feb 17, 2017. （申请）

6. Patent number: 200410040796.X. The preparation and the application of an antifungal reagent

一种防治植物寄生线虫的生防制剂，张楹等，专利号：ZL 03135134.4，授权时间2005年

7. Materials and methods for treatment of severe combined immunodeficiency (SCID) or omenn syndrome. Ying ZHANG, Chad Albert COWAN, Ante Sven LUNDBERG, Gregory Joseph COST. PCT/IB2017/000200

8. The preparation and the application of an antifungal reagent. Ying ZHANG. 200410040796.X.

发表著作

Book Chapter "Genome Editing for Genetic Lung Diseases" Pharmaceutical Inhalation Aerosol Technology Third Edition.

课题组积极招收学生和博士后加入！