Dual-Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis

Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance

Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response

The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS

DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

20220913 CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression

20220819 The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation

20220817 Renal NF-kappaB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting