STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2

SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability

Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis

A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA

The CEP170B-KIF2A complex destabilizes microtubule minus ends to generate polarized microtubule network

The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma