Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy

UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

Fast and sensitive CRISPR detection by minimized interference of target amplification

Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses